Churchill Valenzuela

Brassica oleracea var acephala was studied for preliminary phytochemical screening. The results showed that the ethanolic crude extract of the leaf contain high phytochemical activity hence B.oleracea var acephala is rich in flavonoids, phenolic compounds, carbohydrates and phytosterols.

The ethanolic extract was used to synthesise copper…[Read more]

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a recently validated therapeutic target for lowering low-density lipoprotein cholesterol (LDL-C). Through phenotypic screening, we previously discovered a class of small-molecules with a 2,3′-diindolymethane (DIM) skeleton that can decrease the expression of PCSK9. But these compounds have…[Read more]

Serum microRNA-18a and/or microRNA-21 might serve as non-invasive diagnostic markers in colorectal cancer, while serum microRNA-92a is better to be combined with either microRNA-18a or microRNA-21 as it has limited usefulness when used as sole diagnostic marker.

Serum microRNA-18a and/or microRNA-21 might serve as non-invasive diagnostic…[Read more]

In this review, we summarize the possible origin and transmission mode of CoVs and the current understanding on the viral genome integrity of known pandemic virus against SARS-CoV-2. We also consider the host immune response and viral evasion based on available clinical evidences which would be helpful to remodel COVID-19 pathogenesis; and hence,…[Read more]

006). Our study provides new data that the CYP2D6*4 polymorphism may be associated with an increased risk to develop MPNs while the GSTP1 Ile105Val polymorphism does not show such an association. To our knowledge, the current study is the first to investigate the relationship between CYP2D6*4 and GSTP1 Ile105Val polymorphisms and the risk of…[Read more]

By tuning the surface coverage of DNAzyme, the sensitivity and dynamic range could be controlled. This sensor also featured high selectivity to Pb2+ ions and simple detection procedure. Successful detection of Pb2+ ions in groundwater indicates that this method has the prospect in the onsite detection of Pb2+ ions in water. Given the variety of…[Read more]

From the obtained experimental results, it is evident that our proposed neural network was capable of separating trucks from other vehicles, with an accuracy of 94.9%, and classifying vehicles into three different classes, with an accuracy of 70.8%. Based on the experimental results, extending sensor arrays as described in the last part of the…[Read more]

e events and serious adverse events were similar in the three groups, except for the percentage of patients with chest pain, which was higher in the continuous-molgramostim group.

In patients with aPAP, daily administration of inhaled molgramostim resulted in greater improvements in pulmonary gas transfer and functional health status than…[Read more]

We next examined the serum concentration of trace elements/minerals in dSSc patients with or without pulmonary fibrosis. The result revealed that the serum concentration of Cu in dSSc patients with pulmonary fibrosis was significantly lower than that in patents without pulmonary fibrosis. Our study provided evidence that serum concentrations of K,…[Read more]