Today, little is still known about the neurocognitive functioning of the individual at risk for suicide in a relevant developmental stage like adolescence. Thus, the main goal of the present work was to analyze the neurocognitive performance of adolescents at high risk for suicide. A total of 1509 adolescents from a stratified random cluster sampling were selected. Adolescents at risk for suicidal behaviors included 83 participants. A comparison group of 83 participants matched by age and gender was also randomly selected from the sample. The Paykel Suicide Scale (PSS) and the University of Pennsylvania Computerized Neurocognitive Battery for children (included 14 tasks assessing five neurobehavioral domains executive functions, episodic memory, complex cognition, social cognition, and sensorimotor speed) were used. Adolescents at risk for suicide revealed statistically significant impairments across different neurocognitive domains including complex cognition, episodic memory and social cognition. No significant differences were found for Sensorimotor and Executive Function domains. Results found in the present study contribute relevant information about the nature of the neurocognitive impairments associated with suicide and add information in order to deeper comprehend the tentative etiology of suicide thoughts and attempts in adolescents with the aim to establish preventive treatments.The aim of this work was to study the growth and nutrient removal efficiency of a mixed microalgal culture with and without the addition of low concentrations (0.5, 1, and 5 g L-1 of total liquid volume in the reactor) of natural zeolite. A control test in which only zeolite was added into a similar membrane photobioreactor was also conducted. The addition of 0.5 g L-1 zeolite to a continuously-fed membrane photobioreactor increased the microalgal biomass concentration from 0.50 to 0.90-1.17 g particulate organic carbon per L while the average ammonium removal efficiency increased from 14% to 30%. Upon microscopic inspection, microalgal cells were observed growing on the surface of zeolite particles, which indicates that zeolite can support attached microalgal growth. With higher zeolite doses (1 and 5 g L-1) inside the reactor, however, the breaking apart of added zeolite particles into finer particles dramatically increased solution turbidity, which likely was not beneficial for microalgal growth and ammonium removal due to reduced light penetration. This work shows that low doses of zeolite can be used as microcarriers to enhance microalgal biomass concentration and ammonium removal efficiency, while minimizing zeolite dose would likely reduce the turbidity effects.Aim Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.Peers play a significant role in adolescent mental well-being and suicidality. While social integration among peers is often assumed to benefit mental health, a growing literature recognizes that peer relationships can increase suicidality. Conceptualizing friends’ disclosure of mental distress as a stressor on teens’ own mental health clarifies how distressed peers relate to suicidal ideation given integration in key social contexts, such as school. This study applies the stress process to examine peer depression and self-harm disclosure as stressors predicting teens’ suicidal ideation. Using cross-sectional data from an understudied context, youth in Saudi Arabia (n = 545, 50% female, mean age = 16.8), models find friends’ disclosure of depression and self-harm are associated with adolescents’ higher suicidal ideation net of their own depression. Teens who are more attached to school see higher risk of suicidality from friends’ depression, while friends’ self-harm predicts higher suicidality overall. Results challenge assumptions of uniformly beneficial social integration by indicating that friends’ mental distress, particularly self-harm, can act as a stressor increasing youth suicidality.The purpose of this study was to survey high school rugby players from a range of ethnic, geographic and socioeconomic backgrounds in New Zealand (NZ) to gain an understanding of concussion knowledge, awareness of NZ Rugby’s (NZR) guidelines and attitudes towards reporting behaviours. Male and female high school rugby players (n= 416) from across NZ were surveyed. The findings indicated that 69% of players had sustained a suspected concussion, and 31% had received a medical diagnosis of concussion. selleck 63% of players indicated they were aware of NZR’s guidelines. Māori and Pasifika players were less likely to be aware of the guidelines compared to NZ European, Adjusted OR 0.5, p = 0.03. Guideline awareness was significantly higher for those from high decile schools when compared to low (Unadjusted OR 1.63, p = 0.04); however, when ethnicity and school locations were controlled for this became non-significant (Adjusted OR= 1.3, p=0.37). The coach was the key individual for the provision of concussion information and disclosure of symptoms for players. The findings of this study will inform the development and delivery of NZR’s community concussion initiative and how these examined factors influence a high school player’s concussion knowledge and reporting behaviour.Background Ovarian cancer is one of the gynecological malignancies responsible for thousands of deaths in women worldwide. Malignant solid tumors are formed by malignant cells and stroma that influence each other, where different types of cells in the stromal environment can be recruited by malignant cells to promote tumor growth and facilitate metastasis. The chronic inflammatory response is increasingly accepted in its relation to the pathophysiology of the onset and development of tumors, sustained cell proliferation in an environment rich in inflammatory cells, growth factors, activated stroma and DNA damage agents may increase the risk to develop a neoplasm.Methods A search for the following keywords was performed in the PubMed database; “Ovarian cancer”, “stroma”, “tumor-associated macrophages”, “cancer-associated fibroblasts”, “cytokines”, “angiogenesis”, “epithelial-mesenchymal transition”, and “extracellular matrix”.Results The articles identified were published in English between 1971 and 2018. A total of 154 articles were selected for further analysis.